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Family Reunion

Scenario: Welcome to the annual family reunion! All the folks here today at the lake are having a wonderful time eating and talking about their health problems. Several family members relate their cancer survival stories (Fred liver cancer; Sandra skin cancer; Glenda breast cancer) and discuss the impact that one child with

cystic fibrosis has had on their lives. We use this family's stories as an entry point for discussion of Mendelian genetics, cell division, gene expression, cancer development, and biotechnology.

Concepts Taught:

Icon Key:
activity
animation
diagram
quiz
text explanation

  • Genetic basis of diseases (relationship of genotypes and phenotypes)
  • Cancer
  • Regulation of cell growth and division
  • Mitosis
  • DNA as genetic information
  • DNA structure
  • DNA replication
  • Information flow DNA-RNA-Proteins
    • Genetic code - nucleotides, codons, and amino acids
    • Transcription
    • Translation
  • Cellular differentiation by regulated gene expression
  • Chromosome structure
  • Dominant and recessive mutations
  • Ploidy
  • Genotypes and Phenotypes
  • Genetic diversity
  • Sexual vs. Asexual Reproduction
  • Meiosis
  • Independent assortment
  • Recombination
  • Germ and Somatic cells
  • Mendelian Genetics/Inheritance
  • Probability
  • Transfer of genetic information/alternatives to sex
  • Incomplete dominance
  • Homozygous vs. Heterozygous
  • Sex-linked traits
  • Codominance
  • Biotechnology in medicine, agriculture, criminology
  • PCR

 

Concept Map:

Concepts Reviewed:

Examples of In-Class Discussion Questions: 


Major Terms Introduced:

Alleles
     Dominant allele
     Recessive allele
Amino acids
Apoptosis
Asexual reproduction
Biotechnology
Cancer
Carcinogens
Cell Cycle
Cell Division
Cell Growth
Chromosome
     Autosomes
     Sex chromosomes
Chromatid (sister chromatids)
Codominance
Codon
Complementary strands
Conjugation
Crossing over
Cystic fibrosis
Cytokinesis

Differentiation
DNA
Gene

Genetic code
Genetic counseling
Genotype
Germ cells

Growth factors
Heritable traits
Heterozygous
Homozygous
Homologous chromosomes

Human Genome Project
Incomplete dominance
Independent assortment
Meiosis
Metastasis

Mitosis
Mutagens
Nondisjunction
Nucleotides
Oncogene

PCR
Pedigree

Phenotype
Ploidy
     Haploid
     Diploid

Probability
Punnett square
Reading frame
Recombinant DNA
RNA

     mRNA
     rRNA
     tRNA
Sex-linked trait
Sexual reproduction

Somatic cell
Transcription
Transduction
Transformation
Translation

Tumor

Related Laboratory Experiments and Tutorials:

Lab 10: How can the genetic composition of bacteria be altered in the laboratory?

Lab 11: How can genetic material be identified in the laboratory?

Text Readings:

Click here for Textbook Readings!

Corresponding Essential Study Partner Segments:

The Essential Study Partner is part of the McGraw-Hill Web Site.
To access it go here
. Then follow these relevant paths below:
  • Genetics > Cell Division >
    • Introduction
    • Prokaryotes
    • Chromosomes
    • Mitosis/Cell Cycle
    • Meiosis
    • Recombination
    • Review of cell division
  • Genetics > DNA >
    • DNA Structures
    • DNA Replication
  • Genetics > Protein Synthesis >
    • Gene Activity
    • Transcription
    • Translation
    • Gene Regulation
  • Genetics > Recombinant DNA >
    • Technology
    • Applications

Many of these are figures and accompanying text, but some are video clips that should help you see the process in action.

Useful WWW sites:

The site for your textbook Life by Ricki Lewis

source Genetic Science Learning Center provides a great tutorial explaining DNA, Genes, and Protein synthesis
source DNA from the BEGINNING provides all sorts of information about Genetics in the form of tutorials. Under classical genetics you will find lots of help on genes, chromosomes, and inheritance. Molecular genetics will help you with DNA, RNA, replication, transcription, translation.
Scientists Cross Pigs with Spinach Scientists in Japan implant spinach genes into pigs to create healthier pork.

source
Tour of a Cell (Read about how two NPR hosts try to discover what DNA sounds like then listen to the tour)

source
Interactive Mitosis Tutorial from San Diego State University. You can use this to review the Cell Cycle or the events of mitosis. (Note: the cell undergoing mitosis has 3 chromosomes so it is NOT diploid)

source
Meiosis Tutorial This tutorial from the University of Arizona may help you understand what meiosis is all about.

source
Cell Division Animations - These tutorial from from Cal State will help you understand mitosis, meiosis, rearrangement of chromosomes during meiosis and crossing over. Don't try to memorize the vocabulary (dyads, monads, etc.), these are explained in simple terms. Concentrate on the movement of the chromosomes and the results.

source
The Cell Cycle from The Biology Project at the University of Arizona will provide you with a good explanation and a little more detail than we discuss. It explains the links to cancer as well.

source
Steve Minchin's Learning Resources - School of Biosciences - University of Birmingham (UK) Very good site -- contains animation and interatctive tutorials on DNA, RNA, and base pairs.

source
Biology Project: Monohybrid Cross Problem Set - Here is a place to go if you need to test your knowledge of basic genetics problems. Each question is associated with an explanation that will help guide you to the correct answer if you answer wrong. Provides a good basic tutorial.

source
Biology Project: Sex-linked Inheritance Problem Set - Here is a place to go if you need help with basic genetics problems. Each question is associated with an explanation that will help guide you to the correct answer if you answer wrong. Provides a good basic tutorial.
Biocomputing in a Nutshell Provides a fair amonunt of general information on amino acids and DNA.

source
Cystic fibrosis Includes interesting facts on cystic fibrosis, plus discussions on new treatments and finding a cure.
Phenyketonuria is a autosomal recessive trait and this tutorial uses it to describe where the mutation is found and its effect at the metabolic (enzyme) and phenotypic (mental retardation) level.

source

Genetics of Cancer Read some case studies about cancer for which there is an inherited susceptibility for it to occur again; learn some of the details of how genes function and what is being learned about the genetics of cancer; talk to others about their experiences with cancer that tend to run in families.


source

Polymerase chain reaction (PCR) Explains what PCR is and how it is used.


source

Human genome project Includes a lengthy list of of articles which discuss the human genome project and has direct lenghts to the full text of these articles.


source

When a cell divides, what happens to its chromosomes? Drag and drop to find out if you know the answers. This exercise covers both mitosis and meiosis.


Textbook Flashcards

The website for your textbook has flashcards organised by chapters. You are only responsible for topics discussed in class. For this scenario, flashcards with the Major Terms Introduced can be found in:

Chapter 8: The Cell Cycle
Chapter 9: Meiosis
Chapter 10: How Inherited Traits are Transmitted
Chapter 11: Chromosomes
Chapter 12: DNA Structure and Replication
Chapter 13: Gene Function